what happens when regeneration is too fast
There are many different diseases that are not at all dangerous to others, but look extremely unpleasant. Sometimes these are features of pigmentation, when people become spotty, sometimes unpleasant externally inflamed or flaky areas of the skin. Many people with similar pathologies are upset that everyone is trying to keep their distance from them and are afraid to touch objects after them so as not to get infected.
Today we will talk about psoriasis. It is a non-contagious disease in which the skin regenerates too quickly. As a result, a person can leave a handful of epidermal scales in the pockets of his jacket and on the seat of the car. Here are the key points I want to highlight:
- What is psoriasis and what it looks like (most often it doesn’t look very good).
- What is usually broken in the genome in this disease.
- Why obesity and smoking can make things worse.
- What to apply topically and why steroids can be dangerous.
- The correct diet has been proven to improve the situation.
- People with psoriasis are the few who benefit from sunbathing.
Disclaimer: I will put a part of the photo under the spoiler, if suddenly this may disturb someone.
What is psoriasis
Psoriasis is a chronic, non-communicable
… It cannot be radically cured, but you can try to minimize its manifestations and improve the quality of life. Both men and women suffer from it in equal measure, and quite often. About 2-4% suffer from psoriasis
… Negroids and Mongoloids suffer much less frequently than Caucasians.
With psoriasis, the patient’s epidermal layer of the skin begins to grow excessively. Normally, if you remember, the epidermis is constantly renewing itself. The lower layers of the skin continuously multiply and gradually move upward. In the process of their migration, keratinocytes gradually accumulate more and more protective keratin in their cytoplasm, lose their nucleus and, in the form of dead, nuclear-free cells, are exfoliated with small particles from the skin surface. These flakes form one of the main components of house dust. In psoriasis, the same process is much more intense. If normally skin cells are renewed every 28-30 days, then with this pathology, a complete replacement of the entire epidermal layer of the skin takes 3-5 days… As a result, a person in the most natural way falls asleep with his scales, “shedding” up to 150 grams of skin every month.
The process involves complex immune cascades involving dendritic cells, macrophages and T-lymphocytes. These cells of the immune system migrate into the epidermis from the deep layers of the dermis and activate inflammation by releasing the corresponding chemical regulatory substances – cytokines. Usually this interleukin-36γ, tumor necrosis factor-α, interleukin-1β, interleukin-6, and interleukin-22… Due to these inflammatory factors, the basal layer stem cells are activated, which begin to divide much more actively. One of the hypotheses suggests a genetic defect in regulatory T-lymphocytes and regulatory interleukin-10.
Sometimes the same inflammatory cytokines are found in the growth zones of nails and joints, where they activate similar inflammatory processes. In this case, psoriatic lesions of the joints and nails may appear.
The most typical manifestations of psoriasis are
–
inflamed areas of hyperkeratosis
where keratinocytes are renewed at an abnormal rate.
Very often you can see characteristic areas hyperkeratosis on the palms…
In younger patients, it is usually more common teardrop psoriasis… In this case, multiple teardrop-shaped papules with hyperkeratosis are formed. Very often, guttate psoriasis is associated with a bacterial infection, usually nasopharynx… Beta hemolytic streptococcus is one of the key causes.
Problems with genetics
About a third of all patients have relatives with the same pathology. Identical twins have a risk of developing psoriasis of about 70% if it began in one of the couple. For fraternal twins – simple brothers – the risks are already in the region of 20%. Studies show that for the onset of the disease, both
genetic factors and environmental influences
…
Key risk factors are mutations in genes that are responsible for the major histocompatibility complex (MHC). Certain mutations in this segment often associated with psoriasis, since it is these areas that indirectly describe the key links of the inflammatory process.
Lifestyle issues
It is not enough to have a genetic predisposition. The pathological process still needs to be started. The same genetic risks of diabetes, for example, need a triggering trigger to trigger the chain. Factors
and can provoke many genetically determined diseases:
- Chronic infections.
- Stress.
- Sharp climate changes when moving.
- Excessive use alcohol…
- Smoking.
- Obesity.
shows that the severity of the course in people with initially overweight is reduced by at least 75% on the PASI scale with tight control over diet and its calorie content. At the same time, the addition of physical exercise had a positive effect on the decrease in body mass index, but did not significantly affect psoriasis.
How to treat
Classification of methods according to their effectiveness and side effects
Cure psoriasis completely impossible… The problem is related to a genetic defect, and at best we can drive him into remission.
The choice of funds with us depends on the severity of the course:
- Mild – local preparations on the affected areas.
- Medium degree – phototherapy with ultraviolet UVB spectrum or UVA in combination with photosensitizers of the psoralen group (PUVA therapy).
- Severe degree – systemic drugs. There may be retinoids (such as acitretin), cyclosporine and methotrexate, as well as biologics (monoclonal antibodies).
In milder forms, topical glucocorticosteroids work most effectively. They are cool, they suppress all cascades of inflammation, but at the same time they have many side effects. With constant and extensive use, glucocorticosteroids begin to have a systemic effect, since they are partially absorbed from the surface of the skin and penetrate into the bloodstream. If these are single papules, then everything is fine. If the lesions are extensive, then glucocorticoids should be used very carefully and
…
The analogs of vitamins of group D also showed themselves perfectly – the same calcipotriol… At the same time, the combination of local steroids and an analogue of vitamin D3 gives even more pronounced effect, judging by the meta-analysis.
It is extremely important not to allow chronically inflamed skin with hyperkeratosis to dry out, as is the case with psoriasis. We have not developed drugs specifically for this pathology, but the principles of therapy here do not differ from other similar pathologies. We have Ceramide SkinSaver for this task. It consists of a combination of natural oils and low molecular weight volatile silicones, which evaporate from the skin, preventing these oils from leaving a greasy mark on it and clogging pores. The active ingredients are dissolved in the oils – these are ceramides and phytosterols, which are important for the formation, or rather the reconstruction of the protective layer of the epidermis. Judging by research, the emollient compositions work best, which, on the one hand, do not allow moisture to escape, and on the other hand, do not interfere with the penetration of ultraviolet radiation. Our composition is just right for this task, since we have brought sunscreens into separate products.
Psoriasis is probably one of the few pathologies where the positive effects of ultraviolet radiation outweigh its negative side effects. After good sunbathing and spa treatment, psoriasis severity index went down up to 75%. Therefore, the use of SPF filters in the case of this pathology should be reduced to the minimum sufficient so as not to burn. Yes, the risks of photoaging and skin hyperpigmentation are increasing, but this is not particularly critical when psoriasis symptoms decrease.
I have psoriasis, what should I do?
Find a good dermatologist to get started. You will communicate with him regularly and adjust your treatment. Here are the key things that can help:
- Eat red fish rich in EPA and DHA (Omega-3 acids). Besides, there is a lot of vitamin D in there, which will help too.
- Go on a low-calorie diet and try to lose weight if you are overweight. It is very often strong improves the situation…
- Patients with psoriasis often increased risk of celiac disease… You may be gluten intolerant. Get diagnosed and donate blood for antigliadin antibodies. If the test is positive – eliminate gluten…
- Use emollients. Can our Ceramide SkinSaver, you can do something similar. The main thing is not to block ultraviolet light.
- Systemic retinoids may to help… Check with your dermatologist.
- Use topical corticosteroid ointments with caution. With long courses, you can domazate to fungal skin lesions and Itsenko-Cushing’s disease.
- Sunbathe in moderation. You are one of the few people who would rather benefit from this. Use the minimum amount of SPF so you don’t burn in the sun.
